piatra . institutepathwaysFinding the next step…
Follow the evidence for endosymbiosis, archaeal ancestry and the timing of mitochondrial acquisition.
Know the parts of a cell and the role of membranes. The opening cell-structure reading supplies a refresher; the later phylogeny papers are technical.
An annotated timeline separating observations from proposed evolutionary sequences.
Mary Ann Clark, Matthew Douglas · Jung Choi · reference
Cell compartments and membranes
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Open the readingMary Ann Clark, Matthew Douglas · Jung Choi · reference
Cell compartments and membranes
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Open the readingBiology 2e: cell structure. Compare compartments and energy-producing structures in the cell types under discussion.
Biology 2e: plasma membranes. Review gradients, transport and the distinction between a boundary and an active membrane.
Lynn Sagan (Margulis) · paper · 1967
Proposed symbiotic partners and exchanges
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Open the readingWilliam Martin · Miklós Müller · paper · 1998
Proposed symbiotic partners and exchanges
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Open the readingOn the Origin of Mitosing Cells. Reconstruct the proposed symbiotic partners and the traces their union should leave.
The Hydrogen Hypothesis for the First Eukaryote. Map the proposed metabolic exchange and its dependence on the partners’ environment.
Nick Lane · William Martin · paper · 2010
Energy estimates and genome-complexity argument
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Open the readingThe Energetics of Genome Complexity. Separate the energy estimates, comparison assumptions and proposed implication for genome size.
Katarzyna Zaremba-Niedzwiedzka et al. · paper · 2017
Genomic methods and observed archaeal cell behaviour
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Open the readingHiroyuki Imachi et al. · paper · 2020
Genomic methods and observed archaeal cell behaviour
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Open the readingAsgard Archaea Illuminate the Origin of Eukaryotic Cellular Complexity. Distinguish genomic observations from the inferred features of an ancestral host.
Isolation of an Archaeon at the Prokaryote–Eukaryote Interface. Separate observed cell behaviour from claims about an evolutionary transition.
Editorial perspectives based on selected works, rather than author-endorsed reading lists.
An editorial comparison of the route’s selected accounts and evidence.
A curated synthesis cannot be neutral or exhaustive. Follow the primary sources when an interpretation matters.
An editorial reconstruction using the selected work of Nick Lane.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
An editorial reconstruction using the selected work of William Martin.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
An editorial reconstruction using the selected work of Lynn Margulis.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
Background, different viewpoints, and further reading.
Reconstruct the proposed symbiotic partners and the traces their union should leave.
Proposed symbiotic partners and exchanges
Compare this account’s mechanism with the preceding reading; note where their predictions differ.
Selected chapters and argument
Extract one claim and distinguish the evidence supporting it from the author’s interpretation.
Full paper; methods and limitations
Map the proposed metabolic exchange and its dependence on the partners’ environment.
Proposed symbiotic partners and exchanges
Separate the energy estimates, comparison assumptions and proposed implication for genome size.
Energy estimates and genome-complexity argument
Compare this account’s mechanism with the preceding reading; note where their predictions differ.
Full paper; methods and limitations
Distinguish genomic observations from the inferred features of an ancestral host.
Genomic methods and observed archaeal cell behaviour
Separate observed cell behaviour from claims about an evolutionary transition.
Genomic methods and observed archaeal cell behaviour
Identify what phylogenetic evidence can distinguish between competing host accounts.
Mitochondrial lineages and competing host reconstructions
Compare shared mitochondrial ancestry with changes inferred after the initial symbiosis.
Mitochondrial lineages and competing host reconstructions
Extract one claim and distinguish the evidence supporting it from the author’s interpretation.
Selected chapters and argument
Use this account to revise your initial explanation and identify an unresolved question.
Selected chapters and argument
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Compare compartments and energy-producing structures in the cell types under discussion.
Cell compartments and membranes
Review gradients, transport and the distinction between a boundary and an active membrane.
Cell compartments and membranes
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Compare energy, membranes and proposed evolutionary sequences without treating one account as a settled history.
Connect questions about complex cells with questions about how cells organise into a body.