piatra . institutepathwaysFinding the next step…
Connect reaction–diffusion, positional information, mechanics and bioelectric control of anatomical form.
Basic cell biology is useful. Reaction–diffusion equations are optional at first; later modelling benefits from calculus and some programming.
A multiscale explanation of one developmental pattern and a proposed perturbation.
Start here if the background is new. Equivalent experience is enough.
Use derivatives and change models if you pursue the optional reaction–diffusion modelling.
Mary Ann Clark, Matthew Douglas · Jung Choi · reference
Cell behaviour and membrane organisation
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Open the readingMary Ann Clark, Matthew Douglas · Jung Choi · reference
Cell behaviour and membrane organisation
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Open the readingBiology 2e: cell structure. Compare compartments and energy-producing structures in the cell types under discussion.
Biology 2e: plasma membranes. Review gradients, transport and the distinction between a boundary and an active membrane.
Alan M. Turing · paper · 1952
Reaction–diffusion and positional-information arguments
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Open the readingLewis Wolpert · paper · 1969
Reaction–diffusion and positional-information arguments
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Open the readingThe Chemical Basis of Morphogenesis. Trace the local interaction and diffusion conditions needed for a spatial pattern.
Positional Information and the Spatial Pattern of Cellular Differentiation. Identify the signal, positional interpretation and cellular response in the proposed mechanism.
Alan M. Turing · paper · 1952
Reaction–diffusion and positional-information arguments
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Open the readingRob Phillips et al. · book · 2012
A simple reaction–diffusion or threshold model
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Open the readingThe Chemical Basis of Morphogenesis. Trace the local interaction and diffusion conditions needed for a spatial pattern.
Physical Biology of the Cell. Choose one simple model relevant to patterning and state how its variables simplify cells.
Michael Levin · paper · 2014
One bioelectric intervention and developmental gene regulation
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Open the readingSean B. Carroll · book · 2005
One bioelectric intervention and developmental gene regulation
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Open the readingMolecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo. Inspect one intervention, its measured result and the proposed explanation of pattern change.
Endless Forms Most Beautiful. Use a developmental-regulation example to compare a genetic account with another patterning mechanism.
Editorial perspectives based on selected works, rather than author-endorsed reading lists.
An editorial comparison of the route’s selected accounts and evidence.
A curated synthesis cannot be neutral or exhaustive. Follow the primary sources when an interpretation matters.
An editorial reconstruction using the selected work of Michael Levin.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
An editorial reconstruction using the selected work of Alan Turing.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
An editorial reconstruction using the selected work of Lewis Wolpert.
This is not an author-endorsed syllabus. The reconstruction highlights selected works and may omit other commitments.
Background, different viewpoints, and further reading.
Trace the local interaction and diffusion conditions needed for a spatial pattern.
Reaction–diffusion and positional-information arguments
Identify the signal, positional interpretation and cellular response in the proposed mechanism.
Reaction–diffusion and positional-information arguments
Extract one claim and distinguish the evidence supporting it from the author’s interpretation.
Selected chapters and argument
Inspect one intervention, its measured result and the proposed explanation of pattern change.
One bioelectric intervention and developmental gene regulation
Reconstruct the main argument and identify the assumptions linking it to the route’s question.
Full paper; methods and limitations
Compare this account’s mechanism with the preceding reading; note where their predictions differ.
Full paper; methods and limitations
Ask how a system-level model can connect to measurements and mechanisms at smaller scales.
Models connecting molecular, cellular and tissue scales
Use a developmental-regulation example to compare a genetic account with another patterning mechanism.
One bioelectric intervention and developmental gene regulation
Reconstruct the main argument and identify the assumptions linking it to the route’s question.
Selected chapters and argument
Choose one simple model relevant to patterning and state how its variables simplify cells.
A simple reaction–diffusion or threshold model
Extract one claim and distinguish the evidence supporting it from the author’s interpretation.
Selected chapters and argument
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Compare compartments and energy-producing structures in the cell types under discussion.
Cell behaviour and membrane organisation
Review gradients, transport and the distinction between a boundary and an active membrane.
Cell behaviour and membrane organisation
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Build the cell-biological background needed to distinguish mechanism from an origin hypothesis.
Named section and worked examples
Connect questions about complex cells with questions about how cells organise into a body.
Compare emergent patterns and developmental models at different levels of explanation.